School of Pharmacy - School of Pharmacy

  • Professor Emeritus
  • LEE, KANG CHOON

Journal Articles

  • (2019)  Emerging PEGylated non-biologic drugs.  EXPERT OPINION ON EMERGING DRUGS.  24,  2
  • (2019)  Targeting of dermal myofibroblasts through death receptor 5 arrests fibrosis in mouse models of scleroderma.  NATURE COMMUNICATIONS.  10,  1
  • (2018)  Chemical chaperone-conjugated exendin-4 as a cytoprotective agent for pancreatic β-cells.  INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY.  105,  1
  • (2018)  Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson's disease.  NATURE MEDICINE.  24,  7
  • (2017)  PEGylated TRAIL ameliorates experimental inflammatory arthritis by regulation of Th17 cells and regulatory T cells.  JOURNAL OF CONTROLLED RELEASE.  267,  Special SI
  • (2017)  Cancer preventive effect of recombinant TRAIL by ablation of oncogenic inflammation in colitis-associated cancer rather than anticancer effect..  ONCOTARGET.  9,  2
  • (2017)  Reducing agent-free synthesis of curcumin-loaded albumin nanoparticles by self-assembly at room temperature.  INTERNATIONAL JOURNAL OF PHARMACEUTICS.  529,  1-2
  • (2017)  Brushing off antigenicity.  NATURE BIOMEDICAL ENGINEERING.  1,  1
  • (2017)  Brushing off antigenicity.  Nature Biomedical Engineering.  1,  1
  • (2017)  The synthesis of tamoxifen-loaded albumin nanoparticles by homogenizers: Optimization and in vitro characterization.  JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY.  41,  1
  • (2016)  Exendins and exendin analogs for diabetic therapy: a patent review (2012-2015).  EXPERT OPINION ON THERAPEUTIC PATENTS.  26,  7
  • (2016)  Trimeric PEG-Conjugated Exendin-4 for the Treatment of Sepsis.  BIOMACROMOLECULES.  17,  3
  • (2015)  Delivery of tumor-homing TRAIL sensitizer with long-acting TRAIL as a therapy for TRAIL-resistant tumors.  JOURNAL OF CONTROLLED RELEASE.  220,  1
  • (2015)  Systemic PEGylated TRAIL treatment ameliorates liver cirrhosis in rats by eliminating activated hepatic stellate cells..  HEPATOLOGY.  63,  1
  • (2015)  What is the future of PEGylated therapies?.  EXPERT OPINION ON EMERGING DRUGS.  20,  4
  • (2015)  Mono-lithocholated exendin-4-loaded glycol chitosan nanoparticles with prolonged antidiabetic effects.  INTERNATIONAL JOURNAL OF PHARMACEUTICS.  495,  1
  • (2015)  Doxorubicin-Bound Albumin Nanoparticles Containing a TRAIL Protein for Targeted Treatment of Colon Cancer.  PHARMACEUTICAL RESEARCH.  33,  3
  • (2015)  In situ facile-forming PEG cross-linked albumin hydrogels loaded with an apoptotic TRAIL protein.  JOURNAL OF CONTROLLED RELEASE.  214,  1
  • (2015)  Differences in electrophoretic behavior between linear and branched PEG-conjugated proteins.  ELECTROPHORESIS.  36,  1
  • (2015)  Hyaluronic acid-tumor necrosis factor-related apoptosis-inducing ligand conjugate for targeted treatment of liver fibrosis.  ACTA BIOMATERIALIA.  12,  1

Publications

  • (2009)  Delivery Techonologies for Biopharmaceuticals Chapter 12: Advanced pulmonary delivery of peptides or proteins using polymeric particles.  WILEY.  Co-author
  • (2003)  대한약전 8개정 해설서.  신일상사.  Co-author
  • (1998)  대한 약전 7개정 해설서.  Co-author

Patent/Intellectual Property

  • 엑센딘의 비강투여용 악제학적 조성물 및 이의 제조방법.  2009-0064852.  20120130.  KOREA, REPUBLIC OF
  • 폴리에틸렌글리콜로 화학적으로 수식된 인간 성장 호르몬, 이의 제조방법 및 용도.  2009-0042035 .  20120103.  KOREA, REPUBLIC OF
  • 암 표적지향형 트랜스페린 - 폴리에틸렌 글리콜이 수식된 트레일, 이의 제조 및 용도.  2009-0088126.  20111212.  KOREA, REPUBLIC OF
  • N - 말단이 수식된 PEG - TRAIL 결합체, 이의 제조 방법 및 이의 용도.  10-2007-0038655.  20090925.  KOREA, REPUBLIC OF
  • 가지 달린 고분자 유도체와 인터페론 결합체를 포함하는 항바이러스제.  10-2002-0002651.  20090305.  KOREA, REPUBLIC OF
  • 항고지혈, 항산화 및 항바이러스 활성을 갖는 참취 추출물 및 그로부터 분리된 화합물.  10-2000-037983-0.  20090130.  KOREA, REPUBLIC OF
  • 비오틴으로 수식된 엑센딘 유도체, 이의 제조방법 및 이의용도.  10-0864584-0000.  20081014.  KOREA, REPUBLIC OF
  • 비오틴과 비오틴-폴리에틸렌글리콜이 접합된 GLP-1유도체, 이의 제조방법 및 이를 포함하는 약학 조성물.  0778633.  20071115.  KOREA, REPUBLIC OF
  • 단백질 또는 펩타이드에 결합되는 다가지의 고분자 유도체와 접합체.  10-0761652-00-00.  20070918.  KOREA, REPUBLIC OF
  • 소수성 담즙산이 접합된 엑센딘-4 유도체, 이의 제조방법및 이를 포함하는 약학 조성물.  10-0746658.  20070731.  KOREA, REPUBLIC OF
  • 새로운 이부프로펜 함유 잴라틴 초미세 미립구.  10-0694235-00-00.  20070306.  KOREA, REPUBLIC OF
  • 고반응성의 가지 달린 고분자 유도체 및 고분자와 단백질 또는 펩타이드의 접합체.  0396983.  20030816.  KOREA, REPUBLIC OF
  • The nasal transmucosal delivery of peptides conjugated with biocompatible polymers.  US6,506,730B1.  20030114.  UNITED STATES
  • 생체적합성고분자가 수식된 펩타이드의 비점막 전달.  0345214.  20020705.  KOREA, REPUBLIC OF

Conference Paper

  • (2016)  Strategic PEGylation: Half-life extension of biologic drugs.  8th International Conference and Exhibition on Pharmaceutics & Novel Drug Delivery Systems.  SPAIN
  • (2015)  Smart PEGylation: Enabling Extended Half-life without Loss of Bioactivity..  2014 CRS Annual Meeting.  UNITED STATES
  • (2015)  PEGylation and Bioconjugation of Peptide and Protein Drugs and there Drug Delivery Systems.  1st International Pharmacy Materials 2015 Symposium.  INDONESIA
  • (2014)  Noble Long-Acting GLP-1 Receptor agonist Analogue.  BIT’S 3RD ANNUAL WORLD CONGRESS OF DIABETES 2014.  CHINA
  • (2014)  Strategic Approach for the PEGylation of GLP-1 Analogues.  17th International Pharmaceutical Technology Symposium.  TURKEY
  • (2011)  PEGylated Peptide and Protein Drugs.  2011년 대한약학회 추계학술대회 초록집.  KOREA, REPUBLIC OF
  • (2011)  Preparation and Characterization of Inhalable Self-assembled Glycol Chitosan Nanogels Containing Palmitylated Exendin-4.  추계 약학회 초록.  KOREA, REPUBLIC OF
  • (2011)  Praparation and Characterization of a Long-acting Anti-diabetic inhalation System of Self-assembled Chitosan Nanogel Containing Fatty-acylated Exendin-4 Peptide.  2011 AAPS 초록.  UNITED STATES
  • (2011)  Preparation and Evaluation of Doxorubicin-loaded Albumin Nanoparticles Surface-conjugated with TNF-related Apoptosis Inducing Ligand (TRAIL) and Transferrin for Dual-cancer Targeting.  2011년 AAPS 초록.  UNITED STATES
  • (2011)  Dual drug delivery system for effective controlled combination cancer therapy.  2011 AAPS Annual Meeting and Exposition.  UNITED STATES
  • (2011)  Local Delivery of Doxorubicin and PEGylated TRAIL loaded PLGA microspheres for Effective and Long-Term Combination Tumor Therapy.  38th Annual Meeting & Exposition of the Controlled Release Society.  UNITED STATES
  • (2011)  Development and Characterization of PEGylated Recombinant Human Growth Hormone (rhGH) Loaded PLGA Microsphere.  2011 대한약학회 춘계 국제학술대회.  KOREA, REPUBLIC OF
  • (2011)  Pharmaceutical Potential of Human Serum Albumin Nanoparticles Surfaced-modified with TNF-related Apoptosis Inducing Ligand (TRAIL) as a Pulmonary Delivery System.  춘계 약학회 초록.  KOREA, REPUBLIC OF
  • (2011)  Preparation and Characterization of Inhalable Doxorubicin-loaded Porous Poly (Lactic-co-Glycolic Acid) Microspheres for Treating Lung Cancer.  춘계 약학회 초록.  KOREA, REPUBLIC OF
  • (2011)  Sequential Delivery of Dual Drug from PLGA Microspheres for Effective Combination Cancer Therapy.  2011 대한약학회 춘계 국제학술대회.  KOREA, REPUBLIC OF
  • (2010)  Improved Biological Half-life and Anti-tumor Activity of Apo2L/TRAIL Using PEG-treated Nanoparticles.  2010 한국약제학회 40주년 국제학술대회.  KOREA, REPUBLIC OF
  • (2010)  Non-invasive Delivery System of Lys27-amine Specific PEGylated Exendin-4.  2010 한국약제학회 40주년 국제학술대회.  KOREA, REPUBLIC OF
  • (2010)  PEGylated TRAIL loaded Poly(lactic-co-glycolic acid) Micoparticles for Effective Colon Tumor Therapy.  2010 한국약제학회 40주년 국제학술대회.  KOREA, REPUBLIC OF
  • (2010)  Preparation and Characterization of PEG-Heparin-based Nanoparticles with Improved Stability for the TRAIL Delivery.  FIP Pharmaceutical Sciences World Congress 2010 in Association with AAPS Annual Meeting and Exposition.  UNITED STATES
  • (2010)  TNF-related Apoptosis inducing Ligand(TRAIL) Loaded Human Serum Albumin(HSA) Nanoparticle for Enhancing Stablitity and Tumor Distribution.  FIP Pharmaceutical Sciences World Congress 2010 in Association with AAPS Annual Meeting and Exposition.  UNITED STATES